Downtown Houston is very busy this coming week, from Monday 9/26 through Wednesday 9/28.
As of this posting, there are still some Downtown Hotels with rooms available. However, if by the time you read this they are also fully booked, you might consider trying a hotel in Houston’s renowned Texas Medical Center. Its only a few miles south of Downtown.
Here’s a website with some great hotel booking information for the Texas Medical Center: http://www.houstonmedicalcenterhotels.com .